Other Small Molecule Programmes
In addition to NRs, novel secreted sequences, and P450s, PharmaCarta™ has identified other interesting targets such a smoking alternatives such as eliquids now under active investigation, including:
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Novel Ion Channels: The Company is investigating several families of ion channels, including a ligand-gated ion channel within a highly druggable family. All known subfamilies have had successful drugs targeted against them.
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Novel ADAMTS: The Company also has a novel ADAMTS metalloproteinase target within a precedented protein family. Its expression is highly localised to an important disease relevant cell type.
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Membrane Progestin/Adiponectin Receptors: The company has identified a number of genes related to the membrane progestin/adiponectin receptor family. This family represents an exciting new class of membrane proteins linked to reproductive health and obesity-related diseases, such as diabetes and atherosclerosis.