Assay development and screening - www.inpharmatica.co.uk

Benefit from BioFocus DPI’s extensive target class and disease area expertise and gain access to an unparalleled source of screening libraries and natural product extracts.

Capabilities

Our services include custom assay development, assay formatting for HTS, and compound screening for hit finding, hit-to-lead and lead optimization:

• Cell line generation

• Assay development

• PrimePath: screening in human primary cells

• Medium and high-throughput screening

• Automated electrophysiology screening

• Compound profiling

• High-content screening

• Multi-parameter screening

Track record

• More than 350 assays developed

• Over 200 hit finding campaigns performed

• Greater than 40% of HTS using cellular assay systems

• Over 30 hit-to-lead and lead optimization projects

• More than 80 clients from pharma, biotech and not-for-profit organizations

Target class experience

Over 350 assays developed for different target classes, with particular expertise in biochemical and cellular assays for ion channels, kinases and GPCRs:

Disease area experience

We have developed disease-relevant assays in human primary cells in 14 different disease areas including:

• Inflammatory diseases

• Bone and joint diseases

• Respiratory diseases

• Neurodegenerative diseases

• Obesity and diabetes

Technologies

Our information-rich and high-throughput screening technologies include:

• Electrophysiology (patch clamp, IonWorks™ Quattro®, PatchXpress®)

• Fluorescence-based screens using membrane potential sensitive dyes and Ca2+ release assays

• High-content screening and multi-parametric detection

• Microfluidic “lab on a chip” platform for kinase profiling

• High-throughput plate imaging

• Radioisotopic assays

World-class screening libraries

• Over 32,000 chemogenomically-derived focused (SoftFocus) compounds including kinase, GPCR and ion channel-focused libraries

• Over 700,000 diverse synthetic compounds

• More than 700 purified natural compounds

• More than 140,000 pre-purified natural product fractions from microbial sources

• Focused virtual collections of compounds created using BioFocus DPI computational expertise

Contact us to learn more about how our assay development and screening expertise can contribute to the success of your drug discovery programs.

BioFocus® and SoftFocus® are registered trademark of Galapagos NV and/or its affiliates

IonWorks® Quattro™ is a trademark of Molecular Devices Corporation


search Target discovery Hit finding biology Assay development and screening - Ion channel screening - PrimePath - Kinase profiling In silico screening Natural product screening Hit finding libraries Hit-to-lead/Lead optimization Predictive drug discovery Compound management Partnerships About us News and events Careers Contact BioFocus DPI Home Galapagos Home Mailing list	Smarter screening: faster results Benefit from BioFocus DPI’s extensive target class and disease area expertise and gain access to an unparalleled source of screening libraries and natural product extracts. Capabilities Our services include custom assay development, assay formatting for HTS, and compound screening for hit finding, hit-to-lead and lead optimization: • Cell line generation • Assay development • PrimePath: screening in human primary cells • Medium and high-throughput screening • Automated electrophysiology screening • Compound profiling • High-content screening • Multi-parameter screening Track record • More than 350 assays developed • Over 200 hit finding campaigns performed • Greater than 40% of HTS using cellular assay systems • Over 30 hit-to-lead and lead optimization projects • More than 80 clients from pharma, biotech and not-for-profit organizations Target class experience Over 350 assays developed for different target classes, with particular expertise in biochemical and cellular assays for ion channels, kinases and GPCRs: Disease area experience We have developed disease-relevant assays in human primary cells in 14 different disease areas including: • Inflammatory diseases • Bone and joint diseases • Respiratory diseases • Neurodegenerative diseases • Obesity and diabetes Technologies Our information-rich and high-throughput screening technologies include: • Electrophysiology (patch clamp, IonWorks™ Quattro®, PatchXpress®) • Fluorescence-based screens using membrane potential sensitive dyes and Ca2+ release assays • High-content screening and multi-parametric detection • Microfluidic “lab on a chip” platform for kinase profiling • High-throughput plate imaging • Radioisotopic assays World-class screening libraries • Over 32,000 chemogenomically-derived focused (SoftFocus) compounds including kinase, GPCR and ion channel-focused libraries • Over 700,000 diverse synthetic compounds • More than 700 purified natural compounds • More than 140,000 pre-purified natural product fractions from microbial sources • Focused virtual collections of compounds created using BioFocus DPI computational expertise Contact us to learn more about how our assay development and screening expertise can contribute to the success of your drug discovery programs. BioFocus® and SoftFocus® are registered trademark of Galapagos NV and/or its affiliates IonWorks® Quattro™ is a trademark of Molecular Devices Corporation	Related links ADME/PK assays Contact us BioFocus DPI Home Galapagos Home