How large does a compound screening collection need to be?

Lipkin, Michael J; Stevens, Adrian P; Livingstone, David J; Harris, C John

Combinatorial Chemistry & High Throughput Screening (2008), 11, 482-493

Automatic QSAR modeling of ADME properties: blood-brain barrier penetration and aqueous solubility

Obrezanova, Olga; Gola, Joelle MR; Champness, Edmund; Segall, Matthew

J Comp Aid Mol Design 2008 (submitted)

Why is it still drug discovery?

Segall, Matthew

European BioPharmaceutical Review, Spring 2008

Gaussian processes: a method for automatic QSAR modeling of ADME properties.

Obrezanova, Olga; Csanyi, Gabor; Gola, Joelle MR; Segall, Matthew

J Chem Inf Model. 2007 Sep-Oct;47(5):1847-57

The role of small- or medium-sized enterprises in drug discovery

Newton, Christopher G

Comprehensive Medicinal Chemistry II, vol 1, ed. Taylor, J.B. and Triggle, D.J. (Elsevier, 2007)

Natural selection

Dudfield, Philip and Hannske, Friedrich

European BioPharmaceutical Review (2006), Autumn  issue, 78-83

Bringing kinases into focus: Efficient drug design through the use of chemogenomic toolkits

Birault, Veronique; Harris, C John; Le, Joelle; Lipkin, Mike; Nerella, Ravi and Stevens, Adrian

Current Medicinal Chemistry (2006), 13(15), 1735-1748

Chemogenomics: Structuring the drug discovery process to gene families

Harris, C John and Stevens, Adrian P

Drug Discovery Today (2006), 11(19/20), 880-888

Can we rationally design promiscuous drugs?

Hopkins, Andrew L; Mason, Jonathon S and Overington, John P

Current Opinion Structural Biology (2006), 16(1), 127-36

Focus on success: using a probablistic approach to achieve an optimal balance of compound properties in drug discovery

Segall, Matthew D; Beresford, Alan P; Gola, Joelle MR; Hawksley, Dan and Tarbit, Mike H

Expert Opinion on Drug Metabolism and Toxicology (2006), 2(2), 325-337

Oxachelin, a novel iron chelator and antifungal agent from Streptomyces sp. GW9/1258

Sontag, Bernd; Gerlitz, Martin; Paululat, Thomas; Rasser, Hans-Falk; Gruen-Wollny, Iris and Hanskke, Friedrich G

Journal of Antibiotics (2006), 59(10), 659-663

A reductionist approach to chemogenomics in the design of drug molecules and focused libraries

Crossley, Roger and Slater, Martin J.

Chemogenomics Knowledge-based Approaches in Drug Discovery, ed. E Jacoby (Imperial College Press, 2006), 85-108 

Biology calls the targets: Combining RNAi and disease biology 

van Es, Helmuth H. G. and Arts, Gert-Jan

Drug Discovery Today (2005), 10(20), 1385-1391

A novel storage and retrieval concept for compound collections on dry film

Topp, Andreas; Zbinden, Peter; Wehner, Hans U. and Regenass, Urs   

JALA (2005), 10(2), 88-97

A preliminary study of the metabolic stability of a series of benzoxazinone derivatives as potent neuropeptide Y5 antagonists

Dordal, Alberto; Lipkin, Mike; Macritchie, Jackie; Mas, Josep; Port, Adriana; Rose, Sally; Salgado, Leonardo; Savic, Vladimir; Schmidt, Wolfgang; Serafini, Maria Teresa; Spearing, William; Torrens, Antoni and Yeste, Sandra  

Bioorganic & Medicinal Chemistry Letters (2005), 15(16), 3679-3684

Andy Southan talks about ion channel research services at BioFocus

Carney, Steve and Southan, Andy  

Drug Discovery Today (2005), 10(23-24), 1585-7 

Cellular assays in drug discovery

Albrecht, Hugo; Brodbeck-Hummel, Daniela; Hoever, Michael; Nickel, Beatrice and Regenass, Urs 

Methods and Principles in Medicinal Chemistry (2004),  21(Molecular Biology in Medicinal Chemistry),  3-47

The evolution of microarrayed compound screening

Hoever, Michael and Zbinden, Peter 

Drug Discovery Today (2004), 9(8), 358-365

What lies in the future for in silico ADME?

Beresford, Alan; Segall, Matthew and Tarbit, Mike

Screening (2004), 3, 22-24

This link is provided with the permission of GIT VERLAG GmbH & Co

The design and preparation of metabolically protected new arylpiperazine 5-HT1A ligands

Tandon, Manish; O'Donnell, Mary-Margaret; Porte, Alex; Vensel, David; Yang, Donglai; Palma, Rocio; Beresford, Alan; Ashwell, Mark A

Bioorg Med Chem Lett. 2004 Apr 5;14(7):1709-12

The design of screening libraries targeted at G-protein coupled receptors

Crossley, Roger

Current Topics in Medicinal Chemistry (2004), 4(6), 581-588

The design, structure, and clinical update of small molecular weight matrix metalloproteinase inhibitors

Skiles, Jerry W.; Gonnella, Nina C. and Jeng, Arco Y

Current Medicinal Chemistry (2004), 11(22), 2911-2977

Libraries from natural product-like scaffolds

Boldi, Armen M.  

Current Opinion in Chemical Biology (2004), 8(3), 281-286

In silico prediction of ADME properties: are we making progress?

Current Opinion Drug Discovery Development (2004), 7(1), 36-42  

Modeling aqueous solubility

Butina, Darko; Gola, Joelle MR

J Chem Inf Comput Sci. 2003 May-Jun;43(3):837-41

Adenoviral vectors expressing siRNAs for discovery and validation of gene function

Arts, Gert-Jan; Langemeijer, Ellen; Tissingh, Rudi; Ma, Libin; Pavliska, Heidi; Dokic, Kristina; Dooijes, Richele; Mesic, Emir; Clasen, Remko; Michiels, Frits; van der Schueren, Jan; Lambrecht, Mark; Herman, Sofie; Brys, Reginald; Thys, Kim; Hoffmann, Marcel; Tomme, Peter; and van Es, Helmuth

Genome Research (2003), 13(10), 2325-2332

Computational design strategies for combinatorial libraries

Rose, Sally and Stevens, Adrian

Current Opinion in Chemical Biology (2003), 7(3), 331-339

One step further towards real high throughput functional genomics

Michiels, Frits; van Es, Helmuth and Tomme, Peter

Trends in Biotechnology (2003), 21(4), 147-148

Suzuki cross-coupling of solid-supported chloropyrimidines with arylboronic acids      

Wade, Janice V. and  Krueger, Clinton A.   

Journal of Combinatorial Chemistry (2003), 5(3), 267-272 

The emerging importance of predictive ADME simulation in drug discovery

Selick, Harold E; Beresford, Alan; Tarbit, Mike

Drug Discov Today. 2002 Jan 15;7(2):109-16

Arrayed adenoviral expression libraries for functional screening

Michiels, Frits; van Es, Helmuth; van Rompaey, Luc; Merchiers, Pascal; Francken, Bart; Pittois, Karen; van der Schueren, Jan; Brys, Reginald; Vandersmissen, Johan; Beirinckx, Filip; Herman, Sofie; Dokic, Kristina; Klaassen, Hugo; Narinx, Evi; Hagers, Annick; Laenen, Wendy; Piest, Ivo; Pavliska, Heidi; Rombout, Yvonne; Langemeijer, Ellen; Ma, Libin; Schipper, Christel; De Raeymaeker, Marc; Schweicher, Stephane; Jans, Mia; van Beeck, Kris; Tsang, Ing-Ren; van de Stolpe, Onno and Tomme, Peter 

Nature Biotechnology (2002), 20(11), 1154-1157

Introduction to combinatorial chemistry

Coffen, David L. and Luithle, Joachim E. A. 

Handbook of Combinatorial Chemistry, ed. Nicolaou, K. C.; Hanko, R. and Hartwig, Wolfgang (Wiley-VCH, 2002), 1, 10-23

Potassium channels: gene family, therapeutic relevance, high-throughput screening technologies and drug discovery    

Ford, John W.; Stevens, Edward B.; Treherne, J. Mark; Packer, Jeremy and Bushfield, Mark 

Progress in Drug Research  (2002), 58, 133-168

Statistical design and application to combinatorial chemistry

Rose, Sally

Drug Discovery Today (2002), 7(2), 133-138 

Solid-phase synthesis of 2,4-diaminoquinazoline libraries

Dener, Jeffrey M.; Lease, Timothy G.; Novack, Aaron R.; Plunkett, Matthew J.; Hocker, Michael D. and Fantauzzi, Pascal P.   

Journal of Combinatorial Chemistry (2001), 3(6), 590-597

ADME/PK as part of a rational approach to drug discovery

Eddershaw, Peter J; Beresford, Alan; Bayliss, Martin K

Drug Discov Today. 2000 Sep;5(9):409-414