The ADME/PK Laboratory consultative approach utilizes industry experienced ADME specialists and modern, high-throughput facilities in both the US and the UK to deliver high quality ADME data rapidly.  See what our customers think. 

Our comprehensive ADME solutions are tailored to fit the needs of your discovery program.

• An ADME/PK expert will be assigned to work with you providing guidance on appropriate screening cascades for project targets to ensure the right data are available for decision making from early discovery through to candidate selection and beyond

• Your assigned expert will provide advice on progressing compounds towards the target product profile efficiently and cost-effectively after reviewing all ADME and DMPK data, whether generated by us or supplied by you

• This value-added service is delivered with speed and quality to maximize research productivity  

More than a contract screening service

Offering the latest in vitro measuremenets for ADME/PK and physicochemical parameters, our range of validated assays is continually expanding (see the ADME/PK Laboratory Catalog).

• Client-specific protocols and additional assay formats can be adopted and validated
• The adaptable ADME/PK Laboratory team has experience with many analytical procedures
• For biotech support our existing methodologies are frequently adapted to provide data on strucures outside the usual definitions of 'drug-like' molecules

Pharmacokinetics and bioanalysis

• ADME/PK Laboratory’s pharmacokinetic (PK) service provides key information for interpretation of in vivo pharmacology findings and assessment of a new drug’s potential for achieving the required ADME profile in man

 • ADME/PK Laboratory has a breadth of experience in the generation, analysis and interpretation of PK data in drug discovery across a variety of species and a broad range of therapeutic targets

 • Bioanalysis for a wide range of fluids and tissue samples is combined with PK parameter calculation and interpretation using compartmental and non-compartmental computer analysis 

Results, delivery and security

• Our ADME/PK specialists extract the greatest value from all ADME and DMPK data and advise on the next steps to move projects forward effectively

 • Routine data processing and management are performed through onsite LIMS, with client data stored in restricted-access files

 • The security level for data transfer is agreed on an individual basis and information is reported in the requested format to ensure compatibility with your company databases and ease of information exchange

Find out more about what the ADME/PK Laboratory has done for other customers and how you can take advantage of the full range of laboratory services to improve your drug discovery process.

Contact us to learn more about our ADME/PK services.